Since Skype comes pre-installed on most Windows 10 devices, it might seem like a tough job to completely remove the application. Recommended: How to Disable Windows 10's Tabs From Showing in Alt+Tab View Disable Skype in Windows 10 Other than taking up a small amount of disk space, Skype could easily hinder your internet connection or experience errors where disk usage shoots up to above 90%. Leaving Skype on your device may or may not cause some “side effects”. In this article, you can learn how to disable or completely remove Skype from your Windows 10 system. However, as time went by, many people started looking for different platforms to expand to. In the past, Skype used to be the biggest private messaging and conferencing application.